Understanding Growth Hormone Deficiency in Adults

What is Growth Hormone DeficiencyGrowth hormone deficiency (GHD) starts with an insufficient amount of the growth hormones (GH) chemical (somatropin) is released from a part of human brain called “Pituitary Gland”. This chemical is responsible to great extent for growth of the human body (as the name indicates) and proper cell reproduction.

Lower levels results in a stunting of the body (growth failure) due to slow rate of growth of the body and higher levels result in diseases known as Gigantism (in children) and Acromegaly (in adults), both resulting from excessive growth of all body parts due to the excessive release of GH.

Human Growth Hormone Deficiency Symptoms

The Action

GH induces protein synthesis in the body. It also raises the blood glucose levels by inhibiting the action of insulin and providing extra glucose for the body tissues to the accelerate growth rate. GH also stimulates the break down of body fat, leading to increased utilization of body fat reducing it quickly in the body. Bone growth occurs as a result of stimulation of protein synthesis in the bones.

Two Types of Growth Hormone Deficiency

Growth Hormone Deficiency in Children

GH deficiency in children results into short stature, small penis, increased body fat and obesity, high-pitched voice, and episodes of low blood sugar levels and faintness due to relatively unopposed insulin action in lowering the blood sugar levels.

GH deficiency in children
My sister is growing!

There are a number of diseases responsible for GH deficiency or failure of GH to produce its effects.

  • GHRH Receptor Mutations
  • Growth Hormone Insensitivity
  • Nutritional Short Stature
  • Psychosocial Short Stature

Caloric deprivation and malnutrition, uncontrolled diabetes, and chronic renal failure can result into failure of GH receptor function properly. Children with these conditions typically exhibit features of acquired short stature with normal or elevated blood levels of GH.

Emotional and social deprivation lead to growth retardation accompanied by delayed speech and excessive eating behavior. A nurturing environment restores growth rates.

Presentation and Diagnosis

Short stature is a common presentation of growth hormone deficiency in children. Short stature should be evaluated comprehensively if a patient’s height is >3 standard deviations (SD) below the mean for age or if the growth rate has decelerated. Skeletal maturation is best evaluated by measuring a radiologic bone age (estimating the bone age by looking at x-ray of the writs). Final height is calculated using various formulas and then present height is compared with it.

Laboratory Investigation

GH deficiency is best assessed by examining the response to stimuli that result in release of GH, including exercise, insulin injection, and other pharmacologic tests that increase GH. Pituitary MRI (MRI scan of brain) may reveal pituitary tumor or structural defects. Molecular analyses for known diseases should be undertaken when the cause of short stature remains undiagnosed or when additional clinical features suggest a genetic cause.


Replacement therapy with recombinant GH restores growth velocity in GH-deficient children to 10 cm/year. You may need to add additional medication if the pituitary gland is defective or underdeveloped.

In patients with GH insensitivity and growth retardation due to GH receptor defects, treatment with IGF-I bypasses the dysfunctional GH receptor.

Taking certain HGH enhancers may help because of the additional amino acids they provide but you should consider speaking to your family health care professional first.

Gowth Hormone Deficiency in Adults

Adult GH Deficiency
`I`m not that short!!

This disorder usually is caused by damage to areas of brain responsible for synthesis and secretion of GH. Damage to pituitary can result into sexual dysfunction and dysfunction of thyroid and/or adrenal gland.

Presentation and Diagnosis

The clinical features include changes in body composition, lipid metabolism, and quality of life and cardiovascular diseases. Body composition changes are common and include reduced lean body mass, increased fat mass with selective deposition of fat into the organs of abdomen, and increased waist-to-hip ratio.

Increased blood level of fats, heart filure, hypertension, and increased plasma fibrinogen levels also may be present. Bones become weak, with resultant increased fracture rates. Patients may experience social isolation, depression, and difficulty maintaining gainful employment.

 Laboratory Investigation

The tests include GH levels after stimulation of growth hormone release (as described for children). IGF-I levels, brain MRI and other scans to look for structural cause of low GH levels.

Treatment: Adult GH Deficiency

Once the diagnosis of adult GH deficiency is established, replacement of GH using a HGH Enhancer that contains particular Pituitary Gland stimulants like the Genf20 Plus a this over the counter treatment is carefully titrated against the body’s needs with the under production of natural growth hormone production.

Why Genf20 Plus can help!

When the pituitary gland is sluggish at producing HGH it can be stimulated into producing more GH by taking key amino acids that trigger it into a producing factory! Much the same as we drink coffee to help stimulate our senses in the morning, it wakes us up and an amino acid like L-Arginine will have the same effect on the pituitary gland. Also there are many types of amino acids that have a direct effect on the production of HGH and on each other actually enhancing how each one works. See Genf20 Plus ingredient list to learn more how these can enhance the natural production of human growth hormones.

I have been using Genf20 for over 5 years now and it has really helped me stay and look younger. When I first saw these results about 4 years ago I could not believe how HGH enhancers have changed my life and they can change other peoples lives as well. My mission is to provide those who are interested in HGH supplements with the correct and honest information about why it works and how it works.


  1. What is the Canadian prevalence of Growth Hormone Deficiency in Adults? Does the prevalence differ between the provinces?

    With Many Thanks!

  2. “Social Isolation”

    Why do Adults with Growth Hormone Deficiency often experience Social Isolation? Is it because the people are conscious and sensitive about the increased adipose tissue around their abdomens? Or is it because the people do not have the energy to socialize with others? All the literature that I have read — both for professionals and laypeople — have just indicated that these people may have social isolation; however, no reason(s) as to “why” the social isolation often occurs.

    I’m a Retired HCP — and I experience Social Isolation with my AGHD (for over 10 years). Even before the AGHD was diagnosed, I knew that “something” was wrong because I was living like a “Hermit.” Once I’m out of the house, I’m okay; but to get me out the door is extremely difficult!

    With Many Thanks!

  3. Please notify me of follow-up comments made to the two questions that I submitted on July 27, 2915 about Adult Growth Hormone Deficiency (i.e., Canadian Prevalence at 6:00 pm; Social Isolation at 7:02 pm).

    With Many Thanks!

Leave a Reply

Your email address will not be published.