Growth hormone deficiency (GHD) starts with an insufficient amount of the growth hormones (GH) chemical (somatropin) is released from a part of human brain called “Pituitary Gland”. This chemical is responsible to great extent for growth of the human body (as the name indicates) and proper cell reproduction.
Lower levels results in a stunting of the body (growth failure) due to slow rate of growth of the body and higher levels result in diseases known as Gigantism (in children) and Acromegaly (in adults), both resulting from excessive growth of all body parts due to the excessive release of GH.
Human Growth Hormone Deficiency Symptoms
GH induces protein synthesis in the body. It also raises the blood glucose levels by inhibiting the action of insulin and providing extra glucose for the body tissues to the accelerate growth rate. GH also stimulates the break down of body fat, leading to increased utilization of body fat reducing it quickly in the body. Bone growth occurs as a result of stimulation of protein synthesis in the bones.
Two Types of Growth Hormone Deficiency
Growth Hormone Deficiency in Children
GH deficiency in children results into short stature, small penis, increased body fat and obesity, high-pitched voice, and episodes of low blood sugar levels and faintness due to relatively unopposed insulin action in lowering the blood sugar levels.
There are a number of diseases responsible for GH deficiency or failure of GH to produce its effects.
- GHRH Receptor Mutations
- Growth Hormone Insensitivity
- Nutritional Short Stature
- Psychosocial Short Stature
Caloric deprivation and malnutrition, uncontrolled diabetes, and chronic renal failure can result into failure of GH receptor function properly. Children with these conditions typically exhibit features of acquired short stature with normal or elevated blood levels of GH.
Emotional and social deprivation lead to growth retardation accompanied by delayed speech and excessive eating behavior. A nurturing environment restores growth rates.
Presentation and Diagnosis
Short stature is a common presentation of growth hormone deficiency in children. Short stature should be evaluated comprehensively if a patient’s height is >3 standard deviations (SD) below the mean for age or if the growth rate has decelerated. Skeletal maturation is best evaluated by measuring a radiologic bone age (estimating the bone age by looking at x-ray of the writs). Final height is calculated using various formulas and then present height is compared with it.
GH deficiency is best assessed by examining the response to stimuli that result in release of GH, including exercise, insulin injection, and other pharmacologic tests that increase GH. Pituitary MRI (MRI scan of brain) may reveal pituitary tumor or structural defects. Molecular analyses for known diseases should be undertaken when the cause of short stature remains undiagnosed or when additional clinical features suggest a genetic cause.
Replacement therapy with recombinant GH restores growth velocity in GH-deficient children to 10 cm/year. You may need to add additional medication if the pituitary gland is defective or underdeveloped.
In patients with GH insensitivity and growth retardation due to GH receptor defects, treatment with IGF-I bypasses the dysfunctional GH receptor.
Taking certain HGH enhancers may help because of the additional amino acids they provide but you should consider speaking to your family health care professional first.
Gowth Hormone Deficiency in Adults
This disorder usually is caused by damage to areas of brain responsible for synthesis and secretion of GH. Damage to pituitary can result into sexual dysfunction and dysfunction of thyroid and/or adrenal gland.
Presentation and Diagnosis
The clinical features include changes in body composition, lipid metabolism, and quality of life and cardiovascular diseases. Body composition changes are common and include reduced lean body mass, increased fat mass with selective deposition of fat into the organs of abdomen, and increased waist-to-hip ratio.
Increased blood level of fats, heart filure, hypertension, and increased plasma fibrinogen levels also may be present. Bones become weak, with resultant increased fracture rates. Patients may experience social isolation, depression, and difficulty maintaining gainful employment.
The tests include GH levels after stimulation of growth hormone release (as described for children). IGF-I levels, brain MRI and other scans to look for structural cause of low GH levels.
Treatment: Adult GH Deficiency
Once the diagnosis of adult GH deficiency is established, replacement of GH using a HGH Enhancer that contains particular Pituitary Gland stimulants like the Genf20 Plus a this over the counter treatment is carefully titrated against the body’s needs with the under production of natural growth hormone production.
Why Genf20 Plus can help!
When the pituitary gland is sluggish at producing HGH it can be stimulated into producing more GH by taking key amino acids that trigger it into a producing factory! Much the same as we drink coffee to help stimulate our senses in the morning, it wakes us up and an amino acid like L-Arginine will have the same effect on the pituitary gland. Also there are many types of amino acids that have a direct effect on the production of HGH and on each other actually enhancing how each one works. See Genf20 Plus ingredient list to learn more how these can enhance the natural production of human growth hormones.